Article
Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.
Genes & development - 1 Dec 1991
Ray P, Higgins K M, Tan J C, Chu T Y, Yee N S, Nguyen H, Lacy E, Besmer P
Abstract excerpt
The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor that is allelic with the murine white-spotting locus (W). W mutations affect melanogenesis, gametogenesis, and hematopoiesis during development and adult life, and they result from the partial or complete loss of c-kit func...
Topics
- Alleles
- Animals
- Female
- Gametogenesis
- Hair Color
- Hematopoiesis
- Male
- Mast Cells
- Melanocytes
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Mutation
- Pedigree
- Phenotype
- Protein-Tyrosine Kinases
- Proto-Oncogene Mas