Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.

doi:10.1242/dev.124.1.65

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Article

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.

Development (Cambridge, England) - 1 Jan 1997

Klüppel M, Nagle D L, Bucan M, Bernstein A

Abstract excerpt

Mutations in the murine dominant white spotting (W) locus cause pleiotropic developmental defects that affect hematopoietic cells, melanocytes, germ cells and the interstitial cells of Cajal in the gut. W mutations either alter the coding sequence of the Kit receptor tyrosine kinase, resulting in...

Topics

Alleles
Animals
Bone Marrow Cells
Cells, Cultured
Chromosome Inversion
Chromosome Mapping
DNA Primers
Embryonic and Fetal Development
Gene Rearrangement
Genes, Regulator
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gestational Age

Mast Cells

Melanocytes

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 9006068
DOI: 10.1242/dev.124.1.65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9006068-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.PMID 9006068Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of KitSemantic proximity Read ↗

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The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Strain-specific white-spotting patterns in laboratory mice.Semantic proximity Read ↗

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Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.Semantic proximity Read ↗

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Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

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