Article
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.
Molecular and cellular biology - 1 Jun 1991
Rottapel R, Reedijk M, Williams D E, Lyman S D, Anderson D M, Pawson T, Bernstein A
Abstract excerpt
The W/c-kit and Steel loci respectively encode a receptor tyrosine kinase (Kit) and its extracellular ligand, Steel factor, which are essential for the development of hematopoietic, melanocyte, and germ cell lineages in the mouse. To determine the biochemical basis of the Steel/W developmental pa...
Topics
- Animals
- Blotting, Western
- Cell Line
- GTPase-Activating Proteins
- Hematopoietic Cell Growth Factors
- Hematopoietic Stem Cells
- Homozygote
- Mast Cells
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation