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Article

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

Molecular and cellular biology - 1 Jun 1991

Rottapel R, Reedijk M, Williams D E, Lyman S D, Anderson D M, Pawson T, Bernstein A

Abstract excerpt

The W/c-kit and Steel loci respectively encode a receptor tyrosine kinase (Kit) and its extracellular ligand, Steel factor, which are essential for the development of hematopoietic, melanocyte, and germ cell lineages in the mouse. To determine the biochemical basis of the Steel/W developmental pathway, we have investigated the response of the Kit tyrosine kinase and several potential cytoplasmic targets to...

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Identifiers

PMID: 1710023
DOI: 10.1128/mcb.11.6.3043-3051.1991
PMCID: PMC360141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.PMID 1710023Read ↗

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.Semantic proximity Read ↗

A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cellsSemantic proximity Read ↗

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

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