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Article

Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2007

Takahashi Taiga, Nosho Katsuhiko, Yamamoto Hiroyuki, Mikami Masashi, Taniguchi Hiroaki, Miyamoto Nobuki, Adachi Yasushi, Itoh Fumio, Imai Kohzoh, Shinomura Yasuhisa

Abstract excerpt

Morphologically, colorectal adenomas can be divided into two groups, protruded-type and flat-type. However, the accurate frequencies of genetic and epigenetic alterations in flat-type colorectal advanced adenomas (laterally spreading tumors) have remained largely unknown. In the current study, we investigated genetic and epigenetic alterations in 101 flat-type colorectal advanced adenomas and 68 protruded-type...

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PMID: 17143260
DOI: 10.1038/modpathol.3800722

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KRAS
BRAF
MGMT
MLH1

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