Article
Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.
Gastroenterology - 1 Aug 2014
Luo Yanxin, Wong Chao-Jen, Kaz Andrew M, Dzieciatkowski Slavomir, Carter Kelly T, Morris Shelli M, Wang Jianping, Willis Joseph E, Makar Karen W, Ulrich Cornelia M, Lutterbaugh James D, Shrubsole Martha J, Zheng Wei, Markowitz Sanford D, Grady William M
Abstract excerpt
BACKGROUND & AIMS: Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenetic and genetic alterations have been detected in conventional tubular adenomas, little is known...
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