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Article

Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma.

The American journal of pathology - 1 Feb 2012

Yagi Koichi, Takahashi Hirokazu, Akagi Kiwamu, Matsusaka Keisuke, Seto Yasuyuki, Aburatani Hiroyuki, Nakajima Atsushi, Kaneda Atsushi

Abstract excerpt

A subset of colorectal cancer shows significant accumulation of aberrant promoter methylation. Previously, we developed two groups of methylation markers that classified colorectal cancer into three epigenotypes: i) high-, ii) intermediate-, and iii) low-methylation epigenotypes. High-methylation epigenotype, with methylation of both group 1 and group 2 markers, correlates to BRAF-mutation((+))....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 22115708
DOI: 10.1016/j.ajpath.2011.10.010

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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