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Article

Genome-wide DNA methylation profiling of primary colorectal laterally spreading tumors identifies disease-specific epimutations on common pathways.

International journal of cancer - 15 Nov 2018

Zhu Liangliang, Yan Feihu, Wang Zhen, Dong Haiyan, Bian Chengling, Wang Ting, Yu Enda, Li Jing

Abstract excerpt

Colorectal laterally spreading tumors (LSTs) grow to extremely large size while rarely invade deeply. Also, there is a low tendency to become cancerous. We used the Illumina Human Methylation 450K array to query the main epigenetic difference of LSTs. We built a discovery cohort with 10 matched cases, and a validation cohort with 9 additional matched cases. Our results suggest that LST displays significant...

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Identifiers

PMID: 30183087
DOI: 10.1002/ijc.31765
PMCID: PMC6495531

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