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Article

Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.

Journal of gastroenterology and hepatology - 1 Mar 2011

Kaji Eisuke, Kato Jun, Suzuki Hideyuki, Akita Mitsuhiro, Horii Joichiro, Saito Shunsuke, Higashi Reiji, Ishikawa Shin, Kuriyama Motoaki, Hiraoka Sakiko, Uraoka Toshio, Yamamoto Kazuhide

Abstract excerpt

BACKGROUND AND AIMS: Laterally-spreading tumors (LST) are a newly-recognized category of colorectal neoplasia, and are defined as lesions larger than 10 mm in diameter and extending circumferentially rather than vertically. However, genetic features of this new category of tumors are not fully elucidated. The aim of this study was to evaluate genetic alterations in LST. METHODS: We examined K-ras, BRAF, and...

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Identifiers

PMID: 21332555
DOI: 10.1111/j.1440-1746.2010.06485.x

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.PMID 21332555Read ↗

TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors.Semantic proximity Read ↗

Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations.Semantic proximity Read ↗

A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations.Semantic proximity Read ↗

Analysis of Ki-ras and p53 gene mutations in laterally spreading tumors of the colorectum.Semantic proximity Read ↗

MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.Semantic proximity Read ↗

Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.Semantic proximity Read ↗

Mutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA.Semantic proximity Read ↗

Analysis of molecular alterations in laterally spreading tumors of the colorectum.Semantic proximity Read ↗

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Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.Semantic proximity Read ↗

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