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Article

TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors.

Cancer science - 1 Jun 2016

Sakai Eiji, Fukuyo Masaki, Matsusaka Keisuke, Ohata Ken, Doi Noriteru, Takane Kiyoko, Matsuhashi Nobuyuki, Fukushima Junichi, Nakajima Atsushi, Kaneda Atsushi

Abstract excerpt

Although most sporadic colorectal cancers (CRC) are thought to develop from protruded adenomas through the adenoma-carcinoma sequence, some CRC develop through flat lesions, so-called laterally spreading tumors (LST). We previously analyzed epigenetic aberrations in LST and found that LST are clearly classified into two molecular subtypes: intermediate-methylation with KRAS mutation and low-methylation with...

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Source

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Identifiers

PMID: 26991699
DOI: 10.1111/cas.12930
PMCID: PMC4968595

Genes

KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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