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Article

Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2006

Mikami Masashi, Nosho Katsuhiko, Yamamoto Hiroyuki, Takahashi Taiga, Maehata Tadateru, Taniguchi Hiroaki, Adachi Yasushi, Imamura Akimichi, Fujita Masahiro, Hosokawa Masao, Itoh Fumio, Imai Kohzoh, Shinomura Yasuhisa

Abstract excerpt

Morphologically, early colorectal tumours can be divided into two groups, protruded-type and flat-type. However, little is known about genetic mechanisms of the latter. We investigated mutations of beta-catenin, KRAS, BRAF, and PIK3CA in 310 early colorectal tumours. beta-catenin mutation was detected in 7.1% of 310 tumours. beta-catenin mutation was detected in a significantly higher percentage of flat-type...

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Identifiers

PMID: 17011185
DOI: 10.1016/j.ejca.2006.06.029

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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