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Article

Methylation epigenotypes and genetic features in colorectal laterally spreading tumors.

International journal of cancer - 1 Oct 2014

Sakai Eiji, Ohata Ken, Chiba Hideyuki, Matsuhashi Nobuyuki, Doi Noriteru, Fukushima Junichi, Endo Hiroki, Takahashi Hirokazu, Tsuji Shingo, Yagi Koichi, Matsusaka Keisuke, Aburatani Hiroyuki, Nakajima Atsushi, Kaneda Atsushi

Abstract excerpt

Aberrant DNA methylation plays an important role in genesis of colorectal cancer (CRC). Previously, we identified Group 1 and Group 2 methylation markers through genome-wide DNA methylation analysis, and classified CRC and protruded adenoma into three distinct clusters: high-, intermediate- and low-methylation epigenotypes. High-methylation epigenotype strongly correlated with BRAF mutations and these aberrations...

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Identifiers

PMID: 24590867
DOI: 10.1002/ijc.28814

Genes

KRAS
BRAF
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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