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Article

Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism.

Molecular pharmacology - 1 Mar 2007

Tsuneki Hiroshi, Kobayashi Soushi, Takagi Kazue, Kagawa Syota, Tsunoda Masahiko, Murata Masahiko, Matsuoka Tadasu, Wada Tsutomu, Kurachi Masayoshi, Kimura Ikuko, Sasaoka Toshiyasu

Abstract excerpt

The alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) gene harbors a high degree of polymorphism. In this study, we found a novel variant (1267 G to A) in exon 10 of the CHRNA7 gene in a Japanese population. This variant results in glycine-to-serine substitution at position 423 (G423S) located in the large cytoplasmic loop of the protein. To clarify the possibility that the G423S mutation alters the...

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Identifiers

PMID: 17132684
DOI: 10.1124/mol.106.030866

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CHRNA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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