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Article

Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors.

Molecular pharmacology - 1 Jul 2006

McLaughlin James T, Fu Jie, Sproul Adrian D, Rosenberg Robert L

Abstract excerpt

alpha-7 Nicotinic acetylcholine receptors (AChRs) exhibit a positive modulation by divalent cations similar to that observed in other AChRs. In the chick alpha7 AChR, this modulation involves a conserved glutamate in loop 9 (Glu172) that undergoes agonist-dependent movements during activation. From these observations, we hypothesized that movements of the nearby beta-sheet formed by the beta7, beta9, and beta10...

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Identifiers

PMID: 16533908
DOI: 10.1124/mol.106.023259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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