Article
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.
Neuropharmacology - 1 Dec 2015
Biaggi-Labiosa Nilza M, Avilés-Pagán Emir, Caballero-Rivera Daniel, Báez-Pagán Carlos A, Lasalde-Dominicci José A
Abstract excerpt
The α4β2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction. These receptors are known to desensitize and up-regulate after chronic nicotine exposure, but the mechanism remains unknown. Currently, the structure and functional role of the intracellular domains of the nAChR are obscure. To study the effect of subunit phosphorylation on α4β2 nAChR function and expression,...
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