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Article

Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes.

The Journal of biological chemistry - 22 Apr 2011

Puskar Nyssa L, Xiu Xinan, Lester Henry A, Dougherty Dennis A

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) are pentameric, neurotransmitter-gated ion channels responsible for rapid excitatory neurotransmission in the central and peripheral nervous systems, resulting in skeletal muscle tone and various cognitive effects in the brain. These complex proteins are activated by the endogenous neurotransmitter ACh as well as by nicotine and structurally related agonists. Activation...

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Identifiers

PMID: 21343288
DOI: 10.1074/jbc.M110.206565
PMCID: PMC3077659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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