Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.

Current pharmaceutical design - 1 Jan 2010

Hajós Mihály, Rogers Bruce N

Abstract excerpt

The most abundant homomeric nicotinic acetylcholine receptors (nAChRs) in the mammalian brain are the pentameric alpha7 nAChRs which consist of five alpha7 subunits, and each subunit provides an orthosteric low affinity binding site for its endogenous ligand, acetylcholine. Distribution and high level expression of alpha7 nAChRs within the limbic circuitry, including the hippocampus and prefrontal cortical areas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Cognition
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drugs, Investigational

Share to Molecular Structure

Share to Nicotinic Agonists

Share to Receptors, Nicotinic

Share to Sensory Gating

Source

Identifiers

PMID: 19909231
DOI: 10.2174/138161210790361434

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.PMID 19909231Read ↗

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptors: from the gene to the disease.Semantic proximity Read ↗

Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A.Semantic proximity Read ↗

Schizophrenia and the alpha7 nicotinic acetylcholine receptor.Semantic proximity Read ↗

Nicotinic receptor channelopathies and epilepsy.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases.Semantic proximity Read ↗

Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes.Semantic proximity Read ↗

Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia.Semantic proximity Read ↗

The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges.Semantic proximity Read ↗

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.Semantic proximity Read ↗

Nicotinic acetylcholine receptors in human genetic disease.Semantic proximity Read ↗

The α7 nicotinic acetylcholine receptor: A mediator of pathogenesis and therapeutic target in autism spectrum disorders and Down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.