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Article

Two rare variations, D478N and D478E, that occur at the same amino acid residue in nicotinic acetylcholine receptor (nAChR) α2 subunit influence nAChR function.

Neuropharmacology - 1 Oct 2014

Dash Bhagirathi, Li Ming D

Abstract excerpt

There occur two rare variations, Asp(D)478Asn(N) and Asp(D)478Glu(E), in the putative cytoplasmic amphipathic α-helices of human nicotinic acetylcholine receptor (nAChR) α2 subunit as a result of mutation in the 1st (G → A: rs141072985) and 3rd (C → A: rs56344740) nucleotide of its 478th triplet codon (GAC). We assessed the effects of these two variations on the function of α2β2- and α2β4-nAChRs as they could...

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Identifiers

PMID: 24950454
DOI: 10.1016/j.neuropharm.2014.05.014
PMCID: PMC4135378

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Source receipt: pubmed, retrieved 7 Sept 2026.

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