Article
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
PloS one - 1 Jan 2015
Zhang Qinhui, Du Yingjie, Zhang Jianliang, Xu Xiaojun, Xue Fenqin, Guo Cong, Huang Yao, Lukas Ronald J, Chang Yongchang
Abstract excerpt
The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and the receptor plays an important role in brain function. In the dbSNP database, there are 55 single nucleotide polymorphisms (SNPs) that cause missense mutations of the human α7nAChR in the coding region. In this study, we tested the impact of 14 SNPs that cause missense mutations in the agonist binding site or the...
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