Article
Functional polymorphisms in the human beta4 subunit of nicotinic acetylcholine receptors.
Neurogenetics - 1 Feb 2005
Liang Yong, Salas Ramiro, Marubio Lisa, Bercovich Dani, De Biasi Mariella, Beaudet Arthur L, Dani John A
Abstract excerpt
Human nicotinic acetylcholine receptor (nAChR) polymorphisms occur in different ethnic populations and may result in differences in nAChR ion channel properties. We have identified four nAChR beta 4 subunit (beta4) nucleotide variants: 392C-->T, 526C-->T, 538A-->G, and 1519A-->G. Their corresponding amino acid substitutions are: Thr to Ile at codon 91 (T91I), Arg to Trp at codon 136 (R136W), Ser to Gly at codon...
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