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Article

Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.

European journal of pharmacology - 5 Feb 1999

Briggs C A, McKenna D G, Monteggia L M, Touma E, Roch J M, Arneric S P, Gopalakrishnan M, Sullivan J P

Abstract excerpt

In the human alpha7 nicotinic receptor, valine-274 in the pore-lining transmembrane-2 region was mutated to threonine to produce the variant human alpha7V274T, which was evaluated electrophysiologically following expression in Xenopus laevis oocytes. Inward current rectification was strong in human alpha7V274T as in the human alpha7 wild type nicotinic receptor. However, human alpha7V274T was 100-fold more...

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Identifiers

PMID: 10082212
DOI: 10.1016/s0014-2999(98)00909-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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