Article
Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Feb 2007
Rozen Daniel E, McGee Lesley, Levin Bruce R, Klugman Keith P
Abstract excerpt
The fitness cost of the genes responsible for resistance to fluoroquinolones in clinical isolates of Streptococcus pneumoniae were estimated in vitro in a common genetic background. Naturally occurring parC, parE, and gyrA loci containing mutations in the quinolone-resistance-determining regions...
Topics
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Mutation
- Pneumococcal Infections
- Streptococcus pneumoniae
- Transformation, Bacterial