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Article

Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Feb 2007

Rozen Daniel E, McGee Lesley, Levin Bruce R, Klugman Keith P

Abstract excerpt

The fitness cost of the genes responsible for resistance to fluoroquinolones in clinical isolates of Streptococcus pneumoniae were estimated in vitro in a common genetic background. Naturally occurring parC, parE, and gyrA loci containing mutations in the quinolone-resistance-determining regions were introduced by transformation into S. pneumoniae strain R6 individually and in combinations. The fitness of these...

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Identifiers

PMID: 17116668
DOI: 10.1128/AAC.01161-06
PMCID: PMC1797730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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