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Article

Impact of fluoroquinolone resistance mutations on gonococcal fitness and in vivo selection for compensatory mutations.

The Journal of infectious diseases - 15 Jun 2012

Kunz Anjali N, Begum Afrin A, Wu Hong, D'Ambrozio Jonathan A, Robinson James M, Shafer William M, Bash Margaret C, Jerse Ann E

Abstract excerpt

BACKGROUND: Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA(91/95) and parC86 mutations on gonococcal fitness. METHODS: Mutant gyrA(91/95) and parC86 alleles were introduced into wild-type gonococci or an isogenic mutant that is resistant to macrolides due to an mtrR(-79)...

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Source

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Identifiers

PMID: 22492860
DOI: 10.1093/infdis/jis277
PMCID: PMC3415892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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