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Article

Interplay in the selection of fluoroquinolone resistance and bacterial fitness.

PLoS pathogens - 1 Aug 2009

Marcusson Linda L, Frimodt-Møller Niels, Hughes Diarmaid

Abstract excerpt

Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling. High-level resistance to fluoroquinolones in E. coli requires the accumulation of multiple mutations, including those that alter target genes and genes regulating drug efflux. Previous studies have shown some...

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Identifiers

PMID: 19662169
DOI: 10.1371/journal.ppat.1000541
PMCID: PMC2714960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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