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Article

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.

Antimicrobial agents and chemotherapy - 1 Jun 2005

Komp Lindgren Patricia, Marcusson Linda L, Sandvang Dorthe, Frimodt-Møller Niels, Hughes Diarmaid

Abstract excerpt

Resistance to fluoroquinolones in urinary tract infection (UTIs) caused by Escherichia coli is associated with multiple mutations, typically those that alter DNA gyrase and DNA topoisomerase IV and those that regulate AcrAB-TolC-mediated efflux. We asked whether a fitness cost is associated with the accumulation of these multiple mutations. Mutants of the susceptible E. coli UTI isolate Nu14 were selected through...

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Identifiers

PMID: 15917531
DOI: 10.1128/AAC.49.6.2343-2351.2005
PMCID: PMC1140522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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