Article
Evolutionary barriers to quinolone resistance in Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2002
Gillespie Stephen H, Voelker Leroy L, Dickens Anne
Abstract excerpt
It is assumed that bacteria always pay a significant physiological price for the acquisition of resistance to antibiotics. To test whether this was the case for a strain of Streptococcus pneumoniae that develops resistance to fluoroquinolone antibiotics, we selected resistance to these agents in a wild-type strain and measured their fitness in comparative growth experiments. The relative growth rate of a mutant...
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