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Article

Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae.

Emerging infectious diseases - 1 Jun 2005

Johnson Crystal N, Briles David E, Benjamin William H, Hollingshead Susan K, Waites Ken B

Abstract excerpt

Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance-determining regions of gyrA and parC. Antimicrobial resistance mutations in housekeeping genes often decrease fitness of microorganisms. To investigate the fitness of quinolone-resistant S. pneumoniae (QRSP), the relative growth efficiencies of 2 isogenic QRSP double mutants were compared...

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Identifiers

PMID: 15963274
DOI: 10.3201/eid1106.040840
PMCID: PMC3367570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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