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Article

Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae.

Emerging infectious diseases - 1 Jun 2005

Johnson Crystal N, Briles David E, Benjamin William H, Hollingshead Susan K, Waites Ken B

Abstract excerpt

Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance-determining regions of gyrA and parC. Antimicrobial resistance mutations in housekeeping genes often decrease fitness of microorganisms. To investigate the fitness of quinolone-resistant S. pneumoniae (QRSP), the relative growth efficiencies of 2 isogenic QRSP double mutants were compared...

Topics

Animals
Anti-Infective Agents
Colony Count, Microbial
DNA Gyrase
DNA Topoisomerase IV
Drug Resistance, Bacterial
Fluoroquinolones
Humans
Lung
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nasopharynx

Pneumonia, Pneumococcal

Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 15963274
DOI: 10.3201/eid1106.040840
PMCID: PMC3367570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15963274-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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