Article
Fitness of Streptococcus pneumoniae fluoroquinolone-resistant strains with topoisomerase IV recombinant genes.
Antimicrobial agents and chemotherapy - 1 Mar 2008
Balsalobre Luz, de la Campa Adela G
Abstract excerpt
The low prevalence of ciprofloxacin-resistant (Cp r) Streptococcus pneumoniae isolates carrying recombinant topoisomerase IV genes could be attributed to a fitness cost imposed by the horizontal transfer, which often implies the acquisition of larger-than-normal parE-parC intergenic regions. A st...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Base Sequence
- Ciprofloxacin
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Recombination, Genetic
- Streptococcus pneumoniae
- Transcription, Genetic