Idiosyncratic variation in the fitness costs of tetracycline-resistance mutations in Escherichia coli.

Abstract excerpt

A bacterium's fitness relative to its competitors, both in the presence and absence of antibiotics, plays a key role in its ecological success and clinical impact. In this study, we examine whether tetracycline-resistant mutants are less fit in the absence of the drug than their sensitive parents, and whether the fitness cost of resistance is constant or variable across independently derived lines....

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