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Article

Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC.

Antimicrobial agents and chemotherapy - 1 Nov 2005

Binet Rachel, Maurelli Anthony T

Abstract excerpt

The fitness cost of a resistance determinant is the primary parameter that determines its frequency in vivo. As a model for analysis of the impact of drug resistance mutations on the intracellular life cycle of Chlamydia spp., we studied the growth of four genetically defined spectinomycin-resistant (Spc(r)) clonal variants of Chlamydia psittaci 6BC isolated in the plaque assay. The development of each variant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16251283
DOI: 10.1128/AAC.49.11.4455-4464.2005
PMCID: PMC1280162

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Source receipt: pubmed, retrieved 7 Sept 2026.

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