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Article

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events.

Cell cycle (Georgetown, Tex.) - 1 Nov 2006

Löffler Harald, Rebacz Blanka, Ho Anthony D, Lukas Jiri, Bartek Jiri, Krämer Alwin

Abstract excerpt

The coordination of mitotic spindle formation and chromatin condensation is an essential prerequisite for successful mitosis. Both events are thought to be initiated by cyclin B/Cdk1, whose initial activation occurs in late prophase at the centrosomes. Recently, we have shown that Chk1 localizes to interphase centrosomes and thereby negatively regulates entry into mitosis by preventing premature activation of...

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Identifiers

PMID: 17106257
DOI: 10.4161/cc.5.21.3435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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