Article
Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells.
The EMBO journal - 21 Jun 2006
Wolf Frank, Wandke Cornelia, Isenberg Nina, Geley Stephan
Abstract excerpt
The disassembly of the mitotic spindle and exit from mitosis require the inactivation of Cdk1. Here, we show that expression of nondegradable cyclinB1 causes dose-dependent mitotic arrest phenotypes. By monitoring chromosomes in living cells, we determined that pronounced overexpression of stable cyclinB1 entailed metaphase arrest without detectable sister chromatid separation, while moderate overexpression...
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