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CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis

9 Jun 2016

Abstract excerpt

Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins. During M phase, chromosomes are segregated by a bipolar array of microtubules called the mitotic spindle. The essential bipolarity of the mitotic spindle is established by the kinesin-5 Eg5, but...

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PMID: 27281342
DOI: 10.1371/journal.pone.0157491

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