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Article

Compartmentalized control of Cdk1 drives mitotic spindle assembly

1 Jan 2022

Abstract excerpt

During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle. During interphase, Cdk1 accumulates in an inactive state, phosphorylated at inhibitory sites by Wee1/Myt1 kinases. At mitosis onset, Cdc25 phosphatase dephosphorylates and...

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PMID: 35081344
DOI: 10.1016/j.celrep.2022.110305

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