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Article

SKP1 drives the prophase I to metaphase I transition during male meiosis.

Science advances - 1 Mar 2020

Guan Yongjuan, Leu N Adrian, Ma Jun, Chmátal Lukáš, Ruthel Gordon, Bloom Jordana C, Lampson Michael A, Schimenti John C, Luo Mengcheng, Wang P Jeremy

Abstract excerpt

The meiotic prophase I to metaphase I (PI/MI) transition requires chromosome desynapsis and metaphase competence acquisition. However, control of these major meiotic events is poorly understood. Here, we identify an essential role for SKP1, a core subunit of the SKP1-Cullin-F-box (SCF) ubiquitin E3 ligase, in the PI/MI transition. SKP1 localizes to synapsed chromosome axes and evicts HORMAD proteins from these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32232159
DOI: 10.1126/sciadv.aaz2129
PMCID: PMC7096161

Genes

SKP1
BUB1
MLH1
PLK1
RPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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