Article

The kinesin-4 family member KIF27 regulates mitotic progression, cytokinesis and genome stability

2026-06-27

Abstract excerpt

Kinesins are microtubule-dependent motors, yet the functions of the kinesin-4 family member KIF27 remain poorly understood. Here, we demonstrate a dynamic and cell-cycle-dependent localization of KIF27, consistent with its functional roles in mitotic progression. Upon mitotic entry, KIF27 relocates to condensed chromosomes. During anaphase, a fraction of KIF27 accumulates at the spindle midzone, and in telophase a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d02f9d87-5312-5c4b-a474-f9f840b29c4b
DOI: 10.64898/2026.06.26.734704

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The kinesin-4 family member KIF27 regulates mitotic progression, cytokinesis and genome stabilityDOI 10.64898/2026.06.26.734704Read

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortexSemantic proximity Read

KIFC1 in cancer: Understanding its expression, regulation, and therapeutic potentialSemantic proximity Read

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancersSemantic proximity Read

KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradationSemantic proximity Read

Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest.Semantic proximity Read

Regulation of midzone microtubule dynamics and abscission in human cells by CAMSAP2 and Kif2aSemantic proximity Read

Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosisSemantic proximity Read

KIF11 silencing and inhibition induces chromosome instability that may contribute to cancerSemantic proximity Read

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell divisionSemantic proximity Read

The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damageSemantic proximity Read

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and agingSemantic proximity Read

Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B.Semantic proximity Read