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Article

Nuclear Chk1 prevents premature mitotic entry.

Journal of cell science - 1 Jul 2011

Matsuyama Makoto, Goto Hidemasa, Kasahara Kousuke, Kawakami Yoshitaka, Nakanishi Makoto, Kiyono Tohru, Goshima Naoki, Inagaki Masaki

Abstract excerpt

Chk1 inhibits the premature activation of the cyclin-B1-Cdk1. However, it remains controversial whether Chk1 inhibits Cdk1 in the centrosome or in the nucleus before the G2-M transition. In this study, we examined the specificity of the mouse monoclonal anti-Chk1 antibody DCS-310, with which the centrosome was stained. Conditional Chk1 knockout in mouse embryonic fibroblasts reduced nuclear but not centrosomal...

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PMID: 21628425
DOI: 10.1242/jcs.086488

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DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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