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Article

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.

Cell - 3 Nov 2006

Branzei Dana, Sollier Julie, Liberi Giordano, Zhao Xiaolan, Maeda Daisuke, Seki Masayuki, Enomoto Takemi, Ohta Kunihiro, Foiani Marco

Abstract excerpt

The Ubc9 SUMO-conjugating enzyme and the Siz1 SUMO ligase sumoylate several repair and recombination proteins, including PCNA. Sumoylated PCNA binds Srs2, a helicase counteracting certain recombination events. Here we show that ubc9 mutants depend on checkpoint, recombination, and replication genes for growth. ubc9 cells maintain stalled-fork stability but exhibit a Rad51-dependent accumulation of cruciform...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17081974
DOI: 10.1016/j.cell.2006.08.050

Genes

PCNA
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.PMID 17081974Read ↗

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Semantic proximity Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Role of SUMO modification of human PCNA at stalled replication fork.Semantic proximity Read ↗

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeastSemantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

A role for SUMO in nucleotide excision repair.Semantic proximity Read ↗

The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.Semantic proximity Read ↗

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.Semantic proximity Read ↗

Sumoylation of MDC1 is important for proper DNA damage response.Semantic proximity Read ↗

Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damageSemantic proximity Read ↗

Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1.Semantic proximity Read ↗

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