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Article

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.

Molecular biology of the cell - 1 Mar 2009

Sollier Julie, Driscoll Robert, Castellucci Federica, Foiani Marco, Jackson Stephen P, Branzei Dana

Abstract excerpt

Recombination is important for DNA repair, but it can also contribute to genome rearrangements. RecQ helicases, including yeast Sgs1 and human BLM, safeguard genome integrity through their functions in DNA recombination. Sgs1 prevents the accumulation of Rad51-dependent sister chromatid junctions at damaged replication forks, and its functionality seems to be regulated by Ubc9- and Mms21-dependent sumoylation. We...

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Identifiers

PMID: 19158389
DOI: 10.1091/mbc.e08-08-0875
PMCID: PMC2655255

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.PMID 19158389Read ↗

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6.Semantic proximity Read ↗

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeastSemantic proximity Read ↗

Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.Semantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

Requirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1.Semantic proximity Read ↗

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Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

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