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Article

The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.

PLoS genetics - 1 Mar 2011

Lee Ming-Ta, Bakir Abla A, Nguyen Kristen N, Bachant Jeff

Abstract excerpt

SUMO conjugation is a key regulator of the cellular response to DNA replication stress, acting in part to control recombination at stalled DNA replication forks. Here we examine recombination-related phenotypes in yeast mutants defective for the SUMO de-conjugating/chain-editing enzyme Ulp2p. We find that spontaneous recombination is elevated in ulp2 strains and that recombination DNA repair is essential for ulp2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Endopeptidases

Share to Methyl Methanesulfonate

Share to Recombination, Genetic

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Identifiers

PMID: 21483811
DOI: 10.1371/journal.pgen.1001355
PMCID: PMC3069114

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The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.PMID 21483811Read ↗

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