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Article

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

PLoS genetics - 1 Mar 2018

Liang Jason, Li Bin-Zhong, Tan Alexander P, Kolodner Richard D, Putnam Christopher D, Zhou Huilin

Abstract excerpt

Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs) selected in the dGCR assay. These dGCRs are formed by non-allelic homologous recombination between divergent DNA sequences mediated by Rad52-,...

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Identifiers

PMID: 29505562
DOI: 10.1371/journal.pgen.1007250
PMCID: PMC5860785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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