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Article

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.

The EMBO journal - 6 Mar 2013

Burkovics Peter, Sebesta Marek, Sisakova Alexandra, Plault Nicolas, Szukacsov Valeria, Robert Thomas, Pinter Lajos, Marini Victoria, Kolesar Peter, Haracska Lajos, Gangloff Serge, Krejci Lumir

Abstract excerpt

Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits Srs2 to sites of replication where Srs2 can disrupt Rad51 filaments and prevent homologous recombination (HR). We report here an unexpected additional mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23395907
DOI: 10.1038/emboj.2013.9
PMCID: PMC3594751

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.PMID 23395907Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

SUMO modification of PCNA is controlled by DNA.Semantic proximity Read ↗

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.Semantic proximity Read ↗

Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.Semantic proximity Read ↗

Role of SUMO modification of human PCNA at stalled replication fork.Semantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.Semantic proximity Read ↗

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.Semantic proximity Read ↗

Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication.Semantic proximity Read ↗

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Semantic proximity Read ↗

DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA.Semantic proximity Read ↗

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