Sumoylation of MDC1 is important for proper DNA damage response.

Abstract excerpt

In response to DNA damage, many DNA damage factors, such as MDC1 and 53BP1, redistribute to sites of DNA damage. The mechanism governing the turnover of these factors at DNA damage sites, however, remains enigmatic. Here, we show that MDC1 is sumoylated following DNA damage, and the sumoylation of MDC1 at Lys1840 is required for MDC1 degradation and removal of MDC1 and 53BP1 from sites of DNA damage. Sumoylated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endodeoxyribonucleases
• Share to Lysine
• Share to Rad51 Recombinase