Article
A role for SUMO in nucleotide excision repair.
DNA repair - 10 Dec 2011
Silver Hannah R, Nissley Jared A, Reed Simon H, Hou Ya-Ming, Johnson Erica S
Abstract excerpt
The two Siz/PIAS SUMO E3 ligases Siz1 and Siz2 are responsible for the vast majority of sumoylation in Saccharomyces cerevisiae. We found that siz1Δ siz2Δ mutants are sensitive to ultra-violet (UV) light. Epistasis analysis showed that the SIZ genes act in the nucleotide excision repair (NER) pathway, and suggested that they participate both in global genome repair (GGR) and in the Rpb9-dependent subpathway of...
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