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Article

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.

Nature - 21 Jul 2005

Pfander Boris, Moldovan George-Lucian, Sacher Meik, Hoege Carsten, Jentsch Stefan

Abstract excerpt

Damaged DNA, if not repaired before replication, can lead to replication fork stalling and genomic instability; however, cells can switch to different damage bypass modes that permit replication across lesions. Two main bypasses are controlled by ubiquitin modification of proliferating cell nuclear antigen (PCNA), a homotrimeric DNA-encircling protein that functions as a polymerase processivity factor and...

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Share to Chromosomes, Fungal
Share to DNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Proliferating Cell Nuclear Antigen

Share to S Phase

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Source

Identifiers

PMID: 15931174
DOI: 10.1038/nature03665

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.PMID 15931174Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Role of SUMO modification of human PCNA at stalled replication fork.Semantic proximity Read ↗

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.Semantic proximity Read ↗

Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.Semantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance.Semantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Semantic proximity Read ↗

Postreplication repair and PCNA modification in Schizosaccharomyces pombe.Semantic proximity Read ↗

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Semantic proximity Read ↗

SUMO modification of PCNA is controlled by DNA.Semantic proximity Read ↗

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