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Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeast

11 Nov 2009

Abstract excerpt

BLM and WRN are members of the RecQ family of DNA helicases, and in humans their loss is associated with syndromes characterized by genome instability and cancer predisposition. As the only RecQ DNA helicase in the yeast Saccharomyces cerevisiae, Sgs1 is known to safeguard genome integrity through its role in DNA recombination. Interestingly, WRN, BLM and Sgs1 are all known to be modified by the small...

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PMID: 19906698
DOI: 10.1093/nar/gkp1008

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