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Article

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.

mBio - 5 May 2020

Arbel Matan, Bronstein Alex, Sau Soumitra, Liefshitz Batia, Kupiec Martin

Abstract excerpt

During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance (DDT) mechanisms that can bypass lesions encountered during DNA replication. PCNA can also be SUMOylated at the same residue or at lysine 127. Surprisingly,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32371600
DOI: 10.1128/mBio.00705-20
PMCID: PMC7403780

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Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.PMID 32371600Read ↗

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Rad51 determines pathway usage in post-replication repair.Semantic proximity Read ↗

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