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Article

Role of SUMO modification of human PCNA at stalled replication fork.

Nucleic acids research - 1 Jul 2012

Gali Himabindu, Juhasz Szilvia, Morocz Monika, Hajdu Ildiko, Fatyol Karoly, Szukacsov Valeria, Burkovics Peter, Haracska Lajos

Abstract excerpt

DNA double-strand breaks (DSBs) can be generated not only by reactive agents but also as a result of replication fork collapse at unrepaired DNA lesions. Whereas ubiquitylation of proliferating cell nuclear antigen (PCNA) facilitates damage bypass, modification of yeast PCNA by small ubiquitin-like modifier (SUMO) controls recombination by providing access for the Srs2 helicase to disrupt Rad51 nucleoprotein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

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Source

Open in PubMed Open full text

Identifiers

PMID: 22457066
DOI: 10.1093/nar/gks256
PMCID: PMC3401441

Genes

PCNA
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Role of SUMO modification of human PCNA at stalled replication fork.PMID 22457066Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Semantic proximity Read ↗

Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.Semantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance.Semantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationSemantic proximity Read ↗

SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.Semantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Postreplication repair and PCNA modification in Schizosaccharomyces pombe.Semantic proximity Read ↗

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forksSemantic proximity Read ↗

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