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Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damage

1 Jan 2013

Abstract excerpt

Genetic information encoded in chromosomal DNA is challenged by intrinsic and exogenous sources of DNA damage. DNA double-strand breaks (DSBs) are extremely dangerous DNA lesions. RAD51 plays a central role in homologous DSB repair, by facilitating the recombination of damaged DNA with intact DNA in eukaryotes. RAD51 accumulates at sites containing DNA damage to form nuclear foci. However, the mechanism of RAD51...

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PMID: 24046452
DOI: 10.1242/jcs.133744

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