Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia.

Cytometry. Part B, Clinical cytometry - 1 Mar 2007

Muñoz Luz, Lasa Adriana, Carricondo Maria T, Hernández Carmen, Ubeda Josep, Nomdedéu Josep F

Abstract excerpt

BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disorder with respect to its clinical course. Accurate identification of prognostic factors is becoming increasingly important in order to determine those patients requiring aggressive treatments. Two of the most predictive outcome markers are the Ig VH mutational gene status and ZAP-70 expression. In earlier reports, both parameters have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Killer Cells, Natural

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Sequence Homology, Nucleic Acid

Share to T-Lymphocytes

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 17051526
DOI: 10.1002/cyto.b.20149

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia.PMID 17051526Read ↗

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia.Semantic proximity Read ↗

ZAP-70 expression and prognosis in chronic lymphocytic leukaemia.Semantic proximity Read ↗

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile.Semantic proximity Read ↗

Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status.Semantic proximity Read ↗

ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia.Semantic proximity Read ↗

Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method.Semantic proximity Read ↗

Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process.Semantic proximity Read ↗

Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression.Semantic proximity Read ↗

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

ZAP-70 staining in chronic lymphocytic leukemia.Semantic proximity Read ↗

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.