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Article

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

The New England journal of medicine - 1 May 2003

Crespo Marta, Bosch Francesc, Villamor Neus, Bellosillo Beatriz, Colomer Dolors, Rozman María, Marcé Silvia, López-Guillermo Armando, Campo Elies, Montserrat Emili

Abstract excerpt

BACKGROUND: The mutational status of immunoglobulin heavy-chain variable-region (IgVH) genes in the leukemic cells of chronic lymphocytic leukemia (CLL) is an important prognostic factor in the disease. We investigated whether the expression of ZAP-70 by CLL cells correlated with the IgVH mutational status, disease progression, and survival. METHODS: The expression of ZAP-70 was analyzed in T-cell and B-cell...

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Identifiers

PMID: 12724482
DOI: 10.1056/NEJMoa023143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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